Synthesis of the Palmitoylated and Farnesylated C-Terminal Lipohexapeptide of the Human N-Ras Protein by Employing an Enzymatically Removable Urethane Protecting Group
✍ Scribed by Prof. Dr. Herbert Waldmann; Dipl.-Chem. Edgar Nägele
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 502 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0044-8249
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✦ Synopsis
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same structure a s C,,, (Fig. 2). Also in this case there is bond length a1ternation"l between 5-6 and 6-6 bonds. Like all 6-6 bonds in thc molecule, the 6-6 C-N bond in C,,N' has doublebond character ( I .37 A) and is even shorter than the C -C double bonds ( I .38 A). The pyrainidalization at the N atom is slightly stronger than that at the C atoms. The highest positivc charge density of0.159 is located at C-2 and the next lowest at C-4 (C-I I ) and C-6 (C-9). Therefore, the resonance structures I -IV (Fig. 2). in particular I and 11. are the most important. (0.159) Ill IV Fig 2 C'Ii:ir~tcii\tic hoiid lengths in A. Mulliken charges ( i n brackets). and the m o s t import:int rooniincc structures of C,,N
Based on this new observation on the generation of the free ions C,,N+ kind C,,N' we are now working on the synthesis and isolation of heterofullerene derivatives such as C,,NR in inacroscopic amounts.