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Synthesis of the macrolide antibiotic, oxolide

✍ Scribed by Brian A. Roden; Sanjay Chemburkar; Leslie Freiberg(dec.); Yi-Yin Ku; Richard Pariza

Book ID
108038846
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
168 KB
Volume
5
Category
Article
ISSN
0960-894X

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## Abstract The three‐dimensional structure of the antibiotic oxolide, (9__S__,11S)‐11‐amino‐9‐deoxo‐11,12‐deoxy‐9,12‐epoxyerythromycin, was determined in CD~2~Cl~2~ through constrained molecular mechanics with constraints derived from proton NMR. The calculations yielded a well‐defined global mini