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Synthesis of the indole series—III: Preparation of 5-, 6-, and 7-cyano and -carboxyindolines and -indoles

✍ Scribed by R. Ikan; E. Rapaport


Publisher
Elsevier Science
Year
1967
Tongue
French
Weight
328 KB
Volume
23
Category
Article
ISSN
0040-4020

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Synthesis of 7-cyano- and 7-acetamido-in
✍ Stanley P. Kolis; Marcella T. Clayton; John L. Grutsch; Margaret M. Faul 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 220 KB

A procedure for the synthesis of 7-cyano and 7-acetamido indoles via cyanocarbonation/hydrogenation of 7-formyl indole is presented. The process can be efficiently scaled up to provide multigram quantities of the desired compounds in good yield. A small survey of substrate scope indicates that the r