✦ LIBER ✦
Synthesis of the host-selective plant toxins AF IIa, AF IIc and AKII, employing sharpless chiral epoxidation under kinetic control
✍ Scribed by Leslie Crombie; Sandra R.M. Jarrett
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 255 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Sharpless chiral epoxidation of the ethyl esters of (2E,4E,6Z) -, (2E,4E,6E)-and (2E,4Z,GE)-8-hydroxy-9-methyldeca-2,4,6,9-tetraenoic acid gave predominantly the (8R,9S)epoxyalcohols. These were converted into the host-specific plant toxins AF Ila, AF Ilc and AK II, thereby effecting a total synthesis of these compounds.