Synthesis of the heterocyclic core of the alkaloids martinelline and martinellic acid
โ Scribed by Mark Hadden; Mark Nieuwenhuyzen; Daire Osborne; Paul J Stevenson; Norris Thompson
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 151 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The tricyclic triamine core 27 of martinellic acid (2) has been prepared stereospecifically in eight steps from 2-hydroxymethylaniline in 11% overall yield. The key steps are the addition of 2hydroxymethylaniline to vinylcyclopropane 14 to prepare cycloaddition precursor 19 in only two steps and an
An expedient method for the assembly of the pyrroloquinoline skeleton found in the martinelline alkaloids using a [3+2] cycloaddition of an azomethine ylide and an alkene has been developed.
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