Synthesis of the Functionalized Macrocyclic Core of Proteasome Inhibitors TMC-95A and B

✍ Scribed by Songnian Lin; Samuel J. Danishefsky

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 95 KB
• Volume: 40
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/1521-3773(20010518)40:10<1967::aid-anie1967>3.0.co;2-q

✦ Synopsis

TMC-95A (1) and its diastereomers, TMC-95B, C, and D (2 ± 4, ), are cyclic peptides recently isolated as fermentation products of Apiospora montagnei Sacc.