✦ LIBER ✦

Synthesis of the fully functionalized tris-oxazole fragment found in metabolites derived from marine organisms

✍ Scribed by Ping Liu; Cassandra A. Celatka; James S. Panek

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 203 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)01218-5

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✦ Synopsis

The synthesis of the fully functionalized tris-oxazole fragment 9 found in marine metabolites kabiramide C and halichondramide is reported employing modified Hantzsch methodology. Starting with the condensation reaction between cinnamamide 1 and ethyl bromopyruvate 2, the synthetic sequence leading to 9 was carried out in 13 steps with an overall yield of 26%.

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