Synthesis of the First Members of a New Class of Biologically Active Bryostatin Analogues
โ Scribed by Wender, Paul A.; De Brabander, Jef; Harran, Patrick G.; Jimenez, Juan-Miguel; Koehler, Michael F. T.; Lippa, Blaise; Park, Cheol-Min; Shiozaki, Makoto
- Book ID
- 126018865
- Publisher
- American Chemical Society
- Year
- 1998
- Tongue
- English
- Weight
- 113 KB
- Volume
- 120
- Category
- Article
- ISSN
- 0002-7863
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Synthesis of a new class of phosphatidylcholine analogues derived from glyceric acid is reported for spectroscopic studies of phospholipases and the conformation of phospholipid side-chains in biological membranes, using fluorescence resonance energy transfer (FRET) techniques.
The synthesis and biological assay of a new series of designed bryostatin analogues modiยฎed at the C20 position are described. These compounds are found to bind to protein kinase C with anities of up to 1.5 nM, demonstrating that variations at C20 can indeed be used to tune anity and potentially fun