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Synthesis of the enantiomers of flavan-4α-ol and flavanone

✍ Scribed by M. Rákosi; A.L. Tőkés; R. Bognár


Publisher
Elsevier Science
Year
1970
Tongue
French
Weight
173 KB
Volume
11
Category
Article
ISSN
0040-4039

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Synthesis of Both Enantiomers of Flavano
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Seebach on the occasion of his 65th birthday An efficient enantiospecific synthesis of the (R)-and (S)-enantiomers of flavanone and 2-methylchromanone is described. The key steps are a C,C-bond formation by ring opening of a chiral epoxide with a dithiane anion, followed by a Mitsunobu cyclization.