✦ LIBER ✦
Synthesis of the dysiherbaine tetrahydropyran core utilizing improved tethered aminohydroxylation conditions
✍ Scribed by Christopher L. Carroll; A. Richard Chamberlin
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- French
- Weight
- 237 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
A concise stereoselective route to the dysiherbaine tetrahydropyran core was achieved in 9 steps and 39% overall yield. Donohoe's improved tethered aminohydroxylation conditions were employed to concurrently install the amino and alcohol groups and construct the tetrahydropyran ring, which features four contiguous cis-stereocenters.