Synthesis of the deculopyranosonic acid analog of N-acetylneuraminic acid, its 5-epimer and 6-epimer, and of 5-acetamido-1,3,5-trideoxy-d-glycero-d-galactonon-2-ulopyranose
β Scribed by Heinz-Werner Hagedorn; Hans Merten; Reinhard Brossmer
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 772 KB
- Volume
- 236
- Category
- Article
- ISSN
- 0008-6215
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π SIMILAR VOLUMES
Glycosidation of N-acetylneuraminic acid by phase-transfer catalysis in chloroform-aqueous alkali gave several known and some new aryl cY-ketosides in a short reaction time and in good yields. The 4-methylumbelliferyl cu-ketoside, the standard substrate for neuraminidase, was prepared in a yield of
The reaction of the peracetate methyl esters of N-acetylneuraminic acid (Neu5Ac), 3-deoxyq~glycero-D-galacto-2-nonulosonic acid (Kdn), and 3-deoxy-D-manno-2-octulosonic acid (Kdo) with trimethylsilyl trifluoromethanesulfonate (CF3SO3SiMe 3) has been reinvestigated. We have found that the choice of s
In extension of the bicyclo-DNA nomenclature (see , Foornote 3), the name tricyclo-DNA and, correspondingly, tricyclo-deoxynucleosides was chosen to denominate this type of nucleotide and nucleoside analog. ## The numbering scheme as depicted in Fig. f for nucleosides was chosen in order to be ab