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Synthesis of the Calicheamicin Aryltetrasaccharide Domain Bearing a Reducing Terminus: Coupling of Fully Synthetic Aglycone and Carbohydrate Domains by the Schmidt Reaction

✍ Scribed by Randall L. Halcomb; Serge H. Boyer; Prof. Dr. Samuel J. Danishefsky


Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
441 KB
Volume
31
Category
Article
ISSN
0044-8249

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✦ Synopsis


The QCM measurements were made on polished, AT-cut crystals (AT: orientation of the cut relative to the crystal axes) with aluminum electrodes operated at a frequency of 9 MHz. A surface roughness of 15%. as measured by nitrogen adsorption isotherms, was taken into account.

[13] The bands at 2975,2888, and 1390 cm-' in the RAIR spectrum reveal the presence of ethoxy groups within the surface-attached APS moiety. The bands at 1089 and 11 18 cm-' are characteristic for siloxane oligomers.

indicating the loss of ethoxy groups and partial cross-linking on the sucface.