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Synthesis of the C6C16 polyene fragment of ratjadone, a potent cytotoxic metabolite from Sorangium cellulosum

✍ Scribed by Eckhard Claus; Markus Kalesse

Book ID: 104261499
Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 188 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)00716-9

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✦ Synopsis

The Pd-catalyzed synthesis of the polyene fragment of ratjadone is described. This strategy employs the Stille-coupling for the coupling of the tetrahydropyran subunit and the Suzuki coupling for attaching the unsaturated lactone to the polyene chain.

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