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Synthesis of the angiotensin-converting enzyme inhibitor (±)-A58365A

✍ Scribed by Derrick L.J Clive; Don M Coltart


Book ID
108386666
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
183 KB
Volume
39
Category
Article
ISSN
0040-4039

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Total synthesis of the angiotensin-conve
✍ Francis G. Fang; Samuel J. Danishefsky 📂 Article 📅 1989 🏛 Elsevier Science 🌐 French ⚖ 262 KB

Annulation of the known vinylogous urethane 4 with a-methyleneglutaric anhydride (3) is the key reaction in a seven step enandospecific synthesis of the ACE inhibitor, A58365A (1). The importance of angiotensin-converting enzyme (ACE) inhibitors in the treatment of hypertension has led to widespread