𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of the Analogues of Lurlenic Acid with Modification in the Side-Chain or in the Aromatic Nucleus: Summary of the Structure−Activity Relationships

✍ Scribed by Shin-ichi Takanashi; Kenji Mori

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
834 KB
Volume
1998
Category
Article
ISSN
1434-193X

No coin nor oath required. For personal study only.

✦ Synopsis

Nine analogues of lurlenic acid {(4E,8E,12E)-14-[2Ј-hydroxy-nate (7), butyl lurlenate (8), the bisdemethyl analogue 9, and the 2Ј-deoxy-2Ј-methyl analogue 10. Structural requirements 3Ј,4Ј-dimethyl-5Ј-(1Љ-β-D-xylopyranosyloxy)phenyl]-4,8,12trimethyltetradeca-4,8,12-trienoic acid (1)}, a component of for the expression of the pheromonal activity is briefly discussed, indicating the importance of the sugar part, the phenolic the mating pheromone of the green flagellate Chlamydomonas allensworthii, were synthesized. They are the (12Z) iso-hydroxy group, the appropriate length and the unsaturation of the side-chain part, and the presence of a polar group at mer 2, the hexahydro derivative 3, the norprenyl analogue 4, the homoprenyl analogue 5, methyl lurlenate (6), ethyl lurle-the terminal position of the side-chain.

📜 SIMILAR VOLUMES

ChemInform Abstract: Pheromone Synthesis
ChemInform Abstract: Pheromone Synthesis. Part 187. Synthesis of the Analogues of Lurlenic Acid with Modification in the Side-Chain or in the Aromatic Nucleus: Summary of the Structure—Activity Relationships.
✍ S. TAKANASHI; K. MORI 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 1 views

In order to clarify structure-activity relationships, nine analogues of the title pheromone (I), which are modified in the side-chain or in the aromatic nucleus, are prepared. The structural requirements for the expression of the pheromonal activity is briefly discussed. The work confirms the import

Structure—Activity Relationships in Side
Structure—Activity Relationships in Side-Chain-Modified Epothilone Analogues — How Important Is the Position of the Nitrogen Atom?
✍ Guido Bold; Severine Wojeik; Giorgio Caravatti; Renate Lindauer; Claire Stierlin 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 8 KB

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.