𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of the 7-hydroxy metabolites of methotrexate and 10-ethyl-10-deazaaminopterin

✍ Scribed by Marcia I. Dawson; David O'Krongly; Peter D. Hobbs; Jose R. Barrueco; Frank M. Sirotnak


Book ID
102408837
Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
416 KB
Volume
76
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Fluorometric high-performance liquid chr
✍ James J. Kinahan; Lawrence L. Samuels; Fouad Farag; Michael P. Fanucchi; Pedro M πŸ“‚ Article πŸ“… 1985 πŸ› Elsevier Science 🌐 English βš– 859 KB

The antifolate compounds IOdeazaaminopterin (lOdAM) and IO-ethyl-IOdeazaaminopterin ( IO-EdAM) are therapeutically superior to methotrexate in transplanted murine tumor systems and in human tumor xenografts growing in immunodeficient "nude" mice. The increased therapeutic index of these analogs corr

Folate analogues: 27. syntheses of 14car
✍ M. M. Nair; Nitin T. Nanavati πŸ“‚ Article πŸ“… 1987 πŸ› John Wiley and Sons 🌐 French βš– 286 KB

vevsi ty o f South A1 abama Mobile, AL 36688 SUMARY 10-Deazaaminopterin (1) and 10-Ethyl-10-deazaaminopterin ( 2 ) labeled uniformly w i t h 14C a t the glutamate moiety were prepared by the following procedure. Uniformly labeled L-glutamic acid was converted t o i t s dimethyl ester (3). -4-Amino-

Dipyridamole mediated enhanced antiproli
✍ Mary Pat Dearing; Mae Jean Englee-Miller; Robert A. Kratzke; Barnett S. Kramer; πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 626 KB

lo-ethyl-1 0-deazaaminopterin (1 0-EDAM) is a rationally designed derivative of the antifolate. methotrexate (MTX). In a number of tumor models these design features have resulted in an improved spectrum of antiproliferative activity as compared with the parent compound. Using an MTT growth assay, w