The synthesis of enantiomerically and diastereomerically pure (-)-(1R,2R,5R)-and (-)-(1R,2S,5R)-2-fluoro frontalin (7)
Synthesis of the 5′-Fluoro-2′β-methyl Analogues of Neplanocin
✍ Scribed by Hiroki Kumamoto; Marina Kobayashi; Nobuyuki Kato; Jan Balzarini; Hiromichi Tanaka
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 298 KB
- Volume
- 2011
- Category
- Article
- ISSN
- 1434-193X
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## Abstract Synthesis of 2′‐deoxy‐2′‐[^18^F]fluoro‐5‐methyl‐1‐__β__‐D‐arabinofuranosyluracil ([^18^F]‐FMAU) is reported. 2‐Deoxy‐2‐[^18^F]fluoro‐1,3,5‐tri‐O‐benzoyl‐__α__‐D‐arabinofuranose **2** was prepared by the reaction of the respective triflate **1** with tetrabutylammonium[^18^F]fluoride. Th
The reaction of [2-14C]-2 ,4-bis-O-(trimethylsilyl)uracil (2) with ~-~-acetyl-~-0-benzoyl-2-deoxy-2-fluoro-~-D-arabinofuranosyl bromide (3) yielded the 3-O-acety1-5-0-benzoyl nucleos e 4 which was hydrolyzed with methanolic ammonia to afford [ 2-feC]-T-( 2-deoxy-2fluoro-p-D-arabinofuranosy1)uracil (