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Synthesis of tetrahydrothiophenes via nucleophilic addition of Harpp's reagent to cyclic carbonates: Application toward the synthesis of breynolide

โœ Scribed by Russell J. Linderman; Neil S. Cutshall; Brian T. Becicka


Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
315 KB
Volume
35
Category
Article
ISSN
0040-4039

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Novel 2-pyrone synthesis via the nucleophilic addition of active methine compounds to 2-alkynone has been developed. The reaction of active methine compounds with 2-alkynone provided 2-pyrones in good yields.