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Synthesis of tetrahetrocyclic systems including pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidine fused with pyrazole derivatives and isolated with 1,3,4-oxa-, thiadiazole, and 1,2,4-tetrazole derivatives

✍ Scribed by Farag A. El-Essawy

Publisher
Journal of Heterocyclic Chemistry
Year
2010
Tongue
English
Weight
121 KB
Volume
47
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

magnified image A series of isolated and fused tetracyclic compounds, containing pyrido[2′,3′:3,4]pyrazolo[1,5‐a]pyrimidine linked with 1,3,4‐oxa‐, thiadiazole, 1,2,4‐tetrazole, and pyrazole derivatives were prepared by the reaction of 1,8,10‐trimethyl‐4‐oxo‐1,4‐dihydropyrido[2′,3′:3,4]pyrazolo[1,5‐a]pyrimidine‐3‐carboxylate and some common reagents to provide the product in satisfactory yields. J. Heterocyclic Chem., (2010).

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## Abstract magnified image __E__‐3‐(__N,N__‐Dimethylamino)‐1‐(3‐methylthiazolo[3,2‐__a__]benzimidazol‐2‐yl)prop‐2‐en‐1‐one (**2**) was synthesized by the reaction of 1‐(3‐methylthiazolo[3,2‐__a__]benzimidazol‐2‐yl)ethanone (**1**) with dimethylformamide‐dimethylacetal. The reaction of **2** with