Synthesis of tacrine derivatives under solventless conditions

✍ Scribed by Mohammad A. Khalilzadeh; Abolfazl Hosseini; Mahmoud Tajbakhsh

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2007
• Tongue: English
• Weight: 238 KB
• Volume: 44
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570440305

✦ Synopsis

Abstract

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Effects of microwave irradiation on the solid‐phase synthesis of tacrine and its derivatives have been evaluated. Preparation of tacrine analogues under conventional conditions suffers from poor synthetic efficiency and usually gives low yield. Reaction of substituted anthranilonitrile with cyclohexanone under microwave irradiation gave a good to excellent yield of the corresponding substituted 9‐amino‐1,2,3,4‐tetrahydroacridines.