An improved synthesis of (−)-syringolide
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Pei Yu; Qi-Guang Wang; Thomas C.W. Mak; Henry N.C. Wong
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Article
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1998
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Elsevier Science
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French
⚖ 345 KB
On treatment with 10% HF, butenolides 4a and 4b afforded enantiopure (-)-syringolides 1 (la) and 2 (lb) respectively in much higher yields. Unprecedentedly, the cyclic acetal 5a was also converted to la by reacting with an excess of p-TsOH. The structure of the ~ynthetic (-)-syringolide 1 (la) was s