Synthesis of sulfur-substituted phospholipid analogs as mechanistic probes of phospholipase A2 catalysis
β Scribed by Yuan, Wei; Fearon, Karen; Gelb, Michael H.
- Book ID
- 120189908
- Publisher
- American Chemical Society
- Year
- 1989
- Tongue
- English
- Weight
- 746 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0022-3263
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The use of conformationally restricted phospholipids 1 and 2 has been employed to understand the conformational preference of phospholipase A2 (PLA2) for substrate phospholipids. Inhibition of porcine pancreatic PLA2 with 1 and 2 indicated a two-to fivefold preference for the distal isomer 2 over th
Synthesis of Substituted Benzoyl Acrylic Acids as Potential Inhibitors of Phospholipase A 2 . -Acylation of long-chain alkylbenzenes with maleic anhydride derivatives under Friedel-Crafts conditions provides access to benzoylacrylic acids [cf. (III)/(IV), (VIII)], which are evaluated for their abili