Synthesis of sulfur-containing aryl and heteroaryl vinyls via Suzuki–Miyaura cross-coupling for the preparation of SERS-active polymers

✍ Scribed by Rolando Perez-Pineiro; Sheng Dai; Ramon Alvarez-Puebla; James Wigginton; Baker Jawabrah Al-Hourani; Hicham Fenniri

• Publisher: Elsevier Science
• Year: 2009
• Tongue: French
• Weight: 309 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2009.07.061

✦ Synopsis

The preparation of sulfur-containing aryl and heteroaryl vinyl co-monomers via Suzuki-Miyaura cross-coupling between the corresponding mercaptomethyl arylboronates and in situ-generated vinyl bromides is described. Surface enhanced Raman scattering (SERS) studies of the target compounds on gold nanoparticles confirmed their potential as spectroscopic tags in the fabrication of SERS-encoded polymers for combinatorial screening and biomedical diagnostics.