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Synthesis of Substituted Pyrrolidines and Pyrrolizidines

โœ Scribed by Adams, Roger; Miyano, Seiji; Nair, M. D.


Book ID
120210119
Publisher
American Chemical Society
Year
1961
Tongue
English
Weight
681 KB
Volume
83
Category
Article
ISSN
0002-7863

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Diastereoselective alkylation of N-acylnorbornene sultams 2 afforded a variety of enantiomerically pure products 3a-3e. Reduction with LiAlH 4 (LAH) followed by ditosylation furnished chiral 1,4-ditosylates 5a-5e which underwent a cyclization reaction with primary amines to afford chiral 1,3-and 1,3