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Synthesis of substituted pyrido[1,2-a]pyrimidines from 2-arylmethylidene-3-fluoroalkyl-3-oxopropionates

โœ Scribed by M. V. Pryadeina; Ya. V. Burgart; M. I. Kodess; V. I. Saloutin


Book ID
106519986
Publisher
Springer
Year
2005
Tongue
English
Weight
373 KB
Volume
54
Category
Article
ISSN
1573-9171

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## Abstract 2โ€Methoxyโ€4โ€aminoโ€5โ€pyrimidinecarbaldehyde (2a) as well as its 6โ€methyl 2b and 6โ€phenyl derivatives 2c were prepared by reduction of the corresponding aminopyrimidinecarbonitriles 1. Catalytic hydrogenation of 1a, 1b gives 5โ€hydroxymethylpyrimidines 3a, 3b; under the same conditions 1c