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Synthesis of substituted 2-mercaptobenzaldehydes and 2-substituted benzo[b]thiophenes

โœ Scribed by Timothy Gallagher; David A Pardoe; Roderick A Porter


Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
128 KB
Volume
41
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


Simple and rapid single-pot preparations of substituted 2-mercaptobenzaldehydes 5 and 2-substituted benzo[b]thiophenes 3 based on ortho-lithiation methodology are described.


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MPHT-Promoted Bromocyclization of ortho-
โœ Maud Jacubert; Abdellatif Tikad; Olivier Provot; Abdallah Hamze; Jean-Daniel Bri ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 558 KB

## Abstract A convenient and general approach to the synthesis of 2โ€substituted 3โ€bromobenzofurans and โ€benzothiophenes was developed. The procedure is based on the cyclization of __ortho__โ€substituted arylalkynes in the presence of __N__โ€methylpyrrolidinโ€2โ€one hydrotribromide (MPHT) as a soft and