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Synthesis of substituted 1,2,4-oxadiazoles from substituted acid chlorides and amidoximes under mild conditions

✍ Scribed by Rajesh O. Bora; Mazahar Farooqui

Book ID
102339232
Publisher
Journal of Heterocyclic Chemistry
Year
2007
Tongue
English
Weight
307 KB
Volume
44
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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Substituted amidoximes have been synthesized, isolated and converted into substituted oxadiazoles as a novel heterocyclic compounds under mild conditions in good to excellent yield.

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## Abstract A series of 4‐cyanobenzenesulfonamides (**1a**, **1b**, **1c**, **1d**, **1e**, **1f**, **1g**, **1h**) was converted to the corresponding __O__‐acetylated amidoximes (**2a**, **2b**, **2c**, **2d**, **2e**, **2f**, **2g**, **2h**). The reaction of **1a** was exemplarily investigated wi