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Synthesis of substituted 10,11-dihydro-5H-dibenz[b,f]azepines; key synthons in syntheses of pharmaceutically active compounds

✍ Scribed by Tine Krogh Jørgensen; Knud Erik Andersen; Jesper Lau; Peter Madsen; Per Olaf Huusfeldt


Publisher
Journal of Heterocyclic Chemistry
Year
1999
Tongue
English
Weight
445 KB
Volume
36
Category
Article
ISSN
0022-152X

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Synthesis of trans-10,11-Dihydro-10,11-d
✍ Roland Heckendorn 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 German ⚖ 532 KB

The stereoselectivity of the reduction of 5-carbamoyl-l0, I 1-dihydro-1 l-oxo-SH-dibenz[bflazepine-lO-yl acetate (6), prepared in two steps from 10, I l-dihydro-lO-oxo-5H-dibenz[hflazepine-5-carboxamide (4), has been studied. Among the reagents used, diisobutylaluminum hydride (DIBAH) was found to g