Synthesis of Starlike N -(2-Hydroxypropyl)methacrylamide Copolymers: Potential Drug Carriers †
✍ Scribed by Wang, Dong; Kopečková, Pavla; Minko, Tamara; Nanayakkara, Vajira; Kopeček, Jindřich
- Book ID
- 127006799
- Publisher
- American Chemical Society
- Year
- 2000
- Tongue
- English
- Weight
- 210 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1525-7797
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The homopolymer of N-(2-hydroxypropy1)methacrylamide (HPMA) and copolymers of HPMA differing in oligopeptide side chains (-Gly-Gly-OH; -Acap-Phe-OH; -Acap-Leu-HMDA and -Gly-Phe-Tyr-OH) or in their content (1.0, 3.5 and 8.4 mol.% of -Gly-Gly-OH side chains). were investigated with respect to their ab
## Abstract __N__‐(2‐Hydroxypropyl)methacrylamide (HPMA) copolymer‐linked nitroxides were synthesized as macromolecular contrast agents for MR imaging. Molar relaxivities of HPMA copolymer‐linked nitroxides increased linearly in proportion to the number of nitroxides attached per gram of copolymer.