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Synthesis of stable functionally substituted nitrile oxides of the aromatic series

โœ Scribed by A. P. Yakubov; D. V. Tsyganov; L. I. Belen'kii; M. M. Krayushkin


Book ID
112448902
Publisher
Springer
Year
1991
Tongue
English
Weight
203 KB
Volume
40
Category
Article
ISSN
1573-9171

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Base-promoted cyclocondensation of hindered nitrile oxides and cyclic diketones affords highly functionalized, sterically-encumbered isoxazole products in good yield. The mild reaction conditions (NEt 3 , EtOH) are tolerant to a wide variety of functionality and permit the preparation of precursors