A Valuable Synthetic Route to Spiro-Cyclopropane Derivatives Containing Multiple Stereogenic Centers. -Tandem double Michael addition-intramolecular nucleophilic substitution reaction of a novel chiral synthon (II) with various oxygen nucleophiles (III) and (V) provides the title spiro-cyclopropane
Synthesis of spiro-cyclopropane derivatives containing multiple chiral centers
โ Scribed by Hui Huang; Qinghua Chen
- Book ID
- 105637880
- Publisher
- SP Science China Press
- Year
- 1999
- Tongue
- English
- Weight
- 589 KB
- Volume
- 42
- Category
- Article
- ISSN
- 1674-7291
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๐ SIMILAR VOLUMES
A user-friendly, one-pot procedure was developed to access racemic as well as enantiomerically enriched cyclopropanes. Thus, the cyclopropanation of olefin (3) was performed using Meldrum's acid (4) or dimethyl malonate (5) and diacetoxyiodobenzene PhI(OAc)2 (6) or iodosyl benzene PhI=O (7) for in s
## Abstract magnified image A series of new spiro[cyclopropaneโ1,4โฒโpyrazolโ3โone] derivatives **3aโh** were synthesized by the reaction of 4โarylideneโ3__H__โpyrazolโ3โone **1** with secondary and tertiary carbanions derived from a methylene and methine group bearing both a leaving group and elec