Synthesis of Specifically Substituted 1-Azaadamantanes
β Scribed by Dr. Nikolaus Risch; Wolfgang Saak
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- English
- Weight
- 200 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract BG9928, a high affinity adenosine A~1~ antagonist, is currently in Phase II clinical trials for the treatment of congestive heart failure. A deuteriumβlabeled version of the molecule was synthesized and used as a standard for __in vivo__ pharmacokinetic and __in vitro__ metabolism studi
Glycosidation of the lactose derivative 4 with [1-13 C]-sialyl sialic acid gave the trisaccharide 5 which was transformed into [1c-13 C]-GM 3 ([1c-13 C]-1). xanthate 3, prepared from enzymatically obtained [1-13 C]-FULL PAPER Scheme 2 Reagents and conditions: (a) PST, AgOTf, CH 3 CN/CH 2 Cl 2 , Οͺ70Β°
## Abstract The first kinetic resolution of racemic 1βazaadamantane derivatives with PLE led to the enantiomers (β)β1 and (β)β2. An unexpected formation of 3 from 1 in aqueous solution was observed.