Synthesis of Spacer-Armed Glucodendrimers Based on the Modification of Poly(propylene Imine) Dendrimers

✍ Scribed by H. W. I. Peerlings; Sergey A. Nepogodiev; J. Fraser Stoddart; E. W. Meijer

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 431 KB
• Volume: 1998
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/(sici)1099-0690(199809)1998:9<1879::aid-ejoc1879>3.0.co;2-8

✦ Synopsis

The use of preformed poly(propylene imine) dendrimers surface concentration variations on the dendrimer properties.

After modification of the dendrimers with these saccharide [DAB(Pa) x ] with reactive primary amine end groups proved to be very useful for the construction of saccharide surface-units, the acetyl protecting groups were removed.

Purification of these derivatives was accomplished by using coated dendrimers. For this purpose, amide bonds were introduced by a reaction between the primary amine end dialysis either in water or in aqueous methanol. The solubility behavior of the resulting glucodendrimers proved groups of the dendrimers with N-succinimidyl-activated esters of spacer-armed acetyl-protected thioglucopyranoside to be strongly dependent on the hydrophobic part, i.e. the alkyl chain spacers in the molecule. Therefore, these units. The linear alkyl chain spacers between the dendrimer surface and the saccharide units was increased in length with nanosized multivalent structures, appropriate for studying carbohydrate-protein interactions, are also proposed useful 1, 5 and 10 carbon atoms. These spacer arms were introduced to determine the influence of local saccharide for investigating amphiphilic properties.