Synthesis of Some Substituted Benzimidazolones
โ Scribed by Clark, Robert L.; Pessolano, Arsenio A.
- Book ID
- 118060123
- Publisher
- American Chemical Society
- Year
- 1958
- Tongue
- English
- Weight
- 547 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0002-7863
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
An efficient liquid-phase synthesis of substituted benzimidazolones 7 is des~bed. Resin bound ofluoronitrobenzene 1 is reacted with various primary amines to afford o-nitroaniline derivatives 2. Subsequent reduction of the aromatic nitro group followed by cyclization gives a PEG bound benzimidazole-
An efficient solid phase synthesis of benzimidazol-2-one-5 carboxylic acid is described. Polymer bound o-fluoronitroaromatic compound 2 was treated with an amine to give o-nitroaniline derivative 3. Reduction of 3 with SnC12 followed by cyclization with DSC gave the benzimidazolone 5. Reaction with