Synthesis of 3,3-dimethylazetidine-2-car
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Norbert De Kimpe; Marc Boeykens; Dirk TourwΓ©
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Article
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1998
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Elsevier Science
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French
β 591 KB
~,-Chloro-a-(N-alkylimino)esters were reduced by sodium cyanoborohydride in methanol in the presence of acetic acid with complete selectivity to give rise to either ~,-chloro-a-(N-alkylamino)esters (reaction at 0Β°C) or 1-alkyl-3,3-dimethylazetidine-2-carboxylic esters (reaction at reflux). The isola