Synthesis of some novel methylene-bis-pyrimidinyl-spiro-4-thiazolidinones as biologically potent agents

✍ Scribed by A. Srinivas; A. Nagaraj; Ch. Sanjeeva Reddy

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2008
• Tongue: English
• Weight: 324 KB
• Volume: 45
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570450428

✦ Synopsis

Abstract

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A series of novel methylene‐bis‐pyrimidinyl‐spiro‐4‐thiazolidinones 6a‐h have been synthesized by cyclocondensation of thioglycolic acid with methylene‐bis‐(N‐cyclohexylidene‐N‐pyrimidine) 5a‐h, which in turn have been prepared by the reaction of cyclohexanone with methylene‐bis‐2‐aminopyrimidines 4a‐h, which are prepared by the reaction of guanidine hydrochloride with methylene‐bis‐chalcones 3a‐h. The compounds 3a‐h have been synthesized by the reaction of 5‐(3‐formyl‐4‐hydroxybenzyl)‐2‐hydroxybenzaldehyde 2 with various acetophenones in presence of KOH. The compound 2 is prepared by the reported method. The structures of the compounds synthesized have been confirmed by their elemental analysis and spectral data. Their antibacterial and antifungal activities have also been evaluated.