✦ LIBER ✦

Synthesis of some new spiro[indoline-3-heterocycle]-2-one derivatives

✍ Scribed by Marzoog S. Al-Thebeiti

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 534 KB
Volume: 5
Category: Article
ISSN: 1042-7163
DOI: 10.1002/hc.520050525

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✦ Synopsis

Indole-2,3-dione ivas treated with malonic acid in a mixture of-ethanol/p?v-idine to afford I - [3-(2-oxoindoliii?.lideiiej]acetic acid (31, ivhich was theta reacted with thionFl chloride to give the corresponding acid chloride (4). The acid chloride 4 reacted with arenes in the presence of AlC1, to Field substituted 3-(2-ox-0indolinylidene)acetophenones 5a-c. Compounds Sac were alkylated with methyl iodide to afford 6a-c. Compounds 6a-c were treated with hydrazine derivatives, hydroxylamine hydrochloride, urea, and thiourea to yield the complex spiro compounds 7a-i, 8ac, and 9a-€, respectively.

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