Synthesis of some new 1-acyl-5-aryl-3-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl)-4,5-dihydro-1H-pyrazole

✍ Scribed by Heng-Shan Dong; Yan-Fei Wang; Guo-Liang Shen; Bin Quan; Wang-Jun Dong

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2011
• Tongue: English
• Weight: 114 KB
• Volume: 49
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.726

✦ Synopsis

Abstract

Some new compounds (E)‐3‐aryl‐1‐(5‐methyl‐1‐p‐tolyl‐1__H__‐1,2,3‐triazol‐4‐yl)‐prop‐2‐en‐1‐ones 5a–e were prepared by 1‐(5‐methyl‐1‐p‐tolyl‐1__H__‐1,2,3‐triazol‐4‐yl)‐ethanone and various aromatic aldehydes. Then one pot reaction was happened by compounds 5a–e with hydrazine hydrate in acetic acid or propionic acid, respectively, to give the title compounds 1acyl‐5‐aryl‐3‐(5‐methyl‐1‐p‐tolyl‐1__H__‐1,2,3‐triazol‐4‐yl)‐4,5‐dihydro‐1__H__‐pyrazoles 6a–i. All structures were established by MS, IR, CHN, ^1^H‐NMR and ^13^C‐NMR spectral data. J. Heterocyclic Chem., (2012).