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Synthesis of Some N-Substituted 3,5-Dimethyl-4-piperidinols and Their Derivatives as Potential Analgesics

✍ Scribed by Harper, Norman J.; Chignell, Colin F.; Kirk, George


Book ID
126034893
Publisher
American Chemical Society
Year
1964
Tongue
English
Weight
385 KB
Volume
7
Category
Article
ISSN
0022-2623

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Synthesis and Photochemistry of 5,5-Dime
✍ Andreas Ihlefeld; Paul Margaretha πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 German βš– 469 KB

In two steps, 5,Sdimethyl-lH-pyrrol-2(5H)-one (3a) was prepared from 5,5-dimethylpyrrolidine-2,4-dione ( = dimethyltetramic acid; 4) in 71 % overall yield (Scheme 1 ) and further converted to N-substituted derivatives 3b-f viu acylation, alkylation, or methoxycarbonylation of its anion (Scheme 2). T