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Synthesis of some heterocyclic imides and azomethine derivatives under solvent free condition and their anti-inflammatory activity evaluation

✍ Scribed by Sham M. Sondhi; Reshma Rani; Amarendra Dhar Diwvedi; Partha Roy

Publisher: Journal of Heterocyclic Chemistry
Year: 2009
Tongue: English
Weight: 118 KB
Volume: 46
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.249

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✦ Synopsis

Abstract

magnified image Condensation of various mono amines with various diacids gave heterocyclic imide derivatives and condensation of amines with various aldehydes gave azomethine derivatives in good yields under solvent free condition. Structures assigned to imide and azomethine derivatives are fully supported by spectral data. All these compounds were screened for anti‐inflammatory activity at a dose of 50 mg/kg p.o. Compound 8a (6‐((tetrahydrofuran‐2‐yl)methyl)‐6H‐pyrrolo[3,4]pyrazine‐5,7‐dione) exhibited anti‐inflammatory activity comparable to standard drug phenyl butazone which showed 37% activity at 50 mg/kg p.o. J. Heterocyclic Chem., 46, 1369, (2009).

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