Synthesis of some disubstituted cyanoacetamides as potential anticonvulsants

✍ Scribed by Herbert F. Schwartz II; Lee F. Worrell; Jaime N. Delgado

• Publisher: John Wiley and Sons
• Year: 1967
• Tongue: English
• Weight: 700 KB
• Volume: 56
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600560117

✦ Synopsis

A series of 17 cyanoacetamides was synthesized for pharrnacologic evaluation. Several synthetic methods were studied: C-alkylation, acylation of amines by ester, and acylation of amines by amides. The Galkylation of cyanoacetamides was investigated in several solvent systems using various bases, and the results are reported. This method was adopted for the alkylation of the cyanoacetamides in a pressurereaction vessel and utilized formamide and/or dimethylsulfoxide as solvent with potassium hydroxide as the basic reagent. Several of the compounds were obtained by the pyrolytic acylation of amine by amide.

N AN EARLIER paper Schwartz and Doerge (1)