✍ Scribed by S. C. Joshi; K. N. Trivedi
No coin nor oath required. For personal study only.
7-Hydroxy-3-phenyl-[4H]-1 -benzopyran4-one la was condensed with 2-bromocyclohexanone to yield the corresponding ether which on alkaline hydrolysis gave tetrahydrodibenzofuran derivative 3 a the pyran ring being opened up during this reaction. Compound was dehydrogenated with DDQ and the benzopyrone ring was constructed on dibenzofuran nucleus with sodium and ethyl fonnate to provide 3-phenyl-[4H]-benzofuro (3,2-g)-l-benzopyran4-one &. Compound & was also synthesized by first converting into corresponding [4H]-l-benzopym-4one @ and then subjecting it to dehydrogenation. A similar series of reactions were employed for 7-hydroxy-8-methyl-3-phenyl-[4H]-1 -benzopyran-4-one &and 7-hydroxy-2-methyl-3-phenyl-[4H]-1 -benzopyran-4-one to obtain 2-hydroxy-1 -methyl-3-phenylacetyl dibenzofuran and 2-methyl-3-phenyl-[4H]-benzofuro (3,2-g)-1 -benzopyran-4-one & respectively.
📜 SIMILAR VOLUMES
## Abstract The synthesis of the __N__‐methylnitrone **11**, __N__‐monoalkylhydroxylamine **9**, __N,N__‐dialkylhydroxylamine **10**, Oxime **8** and other potential metabolites of promethazine **(1)** and of its __N__‐dealkyl derivatives **2,3** are described.