Synthesis of Some 5'-O-Amino Acid Derivatives of Uridine as Potential Inhibitors of UDP-Glucuronosyltransferase. -Several compounds of the type (V) and (VI) are prepared similarly in an attempt to develop the title inhibitors. -(ALARGOV, D. K.; NAYDENOVA, Z.;
✦ LIBER ✦
Synthesis of some 5′-O-amino acid derivatives of uridine as potential inhibitors ofUDP-glucuronosyltransferase
✍ Scribed by D. K. Alargov; Z. Naydenova; K. Grancharov; P. S. Denkova; E. V. Golovinsky
- Publisher
- Springer Vienna
- Year
- 1997
- Tongue
- English
- Weight
- 561 KB
- Volume
- 128
- Category
- Article
- ISSN
- 0026-9247
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## Abstract __o__‐Aminoamide **8**, an intermediate in our multistep synthesisof the title compounds was prepared from 1,3‐diketone **3**. The following condensation of **8** with chloroformamidine‐HCl (**9**) gave pyrido[3,4‐__d__]pyrimidine **10**. Dehydratisation of amide **8** led to __o__‐amin