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Synthesis of some 2,4-diamino-pyrrolo-pyrimidines

✍ Scribed by J R Merchant; Suneel Y Dike


Book ID
113005232
Publisher
Indian Academy of Sciences,Royal Society of Chemistry
Year
1978
Tongue
English
Weight
446 KB
Volume
87
Category
Article
ISSN
0253-4134

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## Abstract Selected examples 2,4‐diamino‐7__H__‐pyrrolo[2,3‐__d__]pyrimidines with a phenyl or benzyl group at the 5‐position were synthesized as inhibitors of dihydrofolate reductase (DHFR) from __Pneumocystis carinΓΌ__ and __Toxoplasma gondii__, two potentially life‐threatening opportunistic path