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Synthesis of some 1,5-benzodiazepin-2-ones

โœ Scribed by Acheson, R. M.; Tully, W. R.


Book ID
121509874
Publisher
The Royal Society of Chemistry
Year
1970
Tongue
English
Weight
777 KB
Volume
8
Category
Article
ISSN
0022-4952

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Solid-phase synthesis of 1,5-benzodiazep
โœ Matthias K. Schwarz; David Tumelty; Mark A. Gallop ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 269 KB

A solid-phase synthesis ofpolysubstituted 1,5-benzodiazepin-2-ones is described. Resinbound 4-fluoro-3-nitrobanzoic acid was reacted with different ~amino acids, followed by nitro group reduction and formation of the seven-membered ring. Subsequent alkylations at N(5) and N(1) afforded the title com