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Synthesis of some 1-(3-hydroxy-4-methoxybenzyl)-2-alkyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinolines and their binding affinities to DA receptor subtypes

✍ Scribed by GA Pinna; G Cignarella; S Scolastico; ML Porceddu


Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
497 KB
Volume
29
Category
Article
ISSN
0223-5234

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The eyntheeia of tetrehydroprotoberberine~' by the reaction of l-benzyl-1,2,3,4-tetrahydroisoquinolinee with formaldehyde by a Pictet-Spengler type reaction' is well documented and provides few,surprises. However, we wish to report on the unueual bchaviour of l-(2-bromo-4,5-methylenedioxy-a-methyl)