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Synthesis of Skeletally Diverse Alkaloid-Like Small Molecules

โœ Scribed by Sarah Murrison; Sushil K. Maurya; Christian Einzinger; Ben McKeever-Abbas; Stuart Warriner; Adam Nelson

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
753 KB
Volume
2011
Category
Article
ISSN
1434-193X

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Short Synthesis of Skeletally and Stereo
Short Synthesis of Skeletally and Stereochemically Diverse Small Molecules by Coupling Petasis Condensation Reactions to Cyclization Reactions
โœ Naoya Kumagai; Giovanni Muncipinto; Stuart L. Schreiber ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 592 KB

Herein, we report a short and efficient synthetic pathway that uses intramolecular cyclization reactions of readily synthesized and densely functionalized amino alcohols. The research illustrates the implementation of a strategy that enables the synthesis, in only three to five steps, of a diverse c