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Synthesis of six new 2-Aryl-N-biphenyl benzimidazoles and crystal structure of methyl 4′ [(2-p-Chlorophenyl-1H-benzimidazole-1-yl)-methyl]biphenyl-2-carboxylate

✍ Scribed by Zhou Zhiming; Yu Weifa; Zhang Jun; Yu Congxuan; Zhao Xinqi

Publisher: Journal of Heterocyclic Chemistry
Year: 2004
Tongue: English
Weight: 240 KB
Volume: 41
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570410424

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✦ Synopsis

Abstract

Six new 2‐aryl‐N‐biphenyl benzimidazoles were designed and synthesized, starting with O‐phenylenediamine and carboxylic acids via cyclization, followed by N‐alkylation. All new compounds were identified by H NMR, IR, MS spectra and elemental analysis. The crystal structure of methyl 4′‐[(2‐p‐chlorophenyl‐1__H__ benzimidazole‐1‐yl)methyl]biphenyl‐2‐carboxylate (4f) was determined by single crystal X‐raydiffraction.

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