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Synthesis of side-chain homologated analogs of 1,25-dihydroxycholecalciferol and 1,25-dihydroxyergocalciferol

โœ Scribed by Micha Chodynski; Andrzej Kutner


Book ID
116065584
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
622 KB
Volume
56
Category
Article
ISSN
0039-128X

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Convergent synthesis, chiral HPLC, and v
โœ Maล‚gorzata Odrzywolska; Michaล‚ Chodyล„ski; Sebastian J. Halkes; Jan-Paul Van De V ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 136 KB

A series of analogs of 1,25-dihydroxycholecalciferol was obtained with an additional chiral center at the terminus of the aliphatic side chain (C-25). The analogs were obtained from (+)-(R)-and (-)-(S)-2-methylglycidols, by opening of the oxirane ring with the carbanions derived from vitamin D C 23a