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Synthesis of several deoxy analogues of pancratistatin

✍ Scribed by LÁSzlÓ Balázs; István Kádas; László Tõke

Book ID
102339344
Publisher
Journal of Heterocyclic Chemistry
Year
1998
Tongue
English
Weight
412 KB
Volume
35
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

N‐Acetylated 1,4,7‐ and 3,4,7‐trideoxypancratistatin analogues 10 and 13 were synthesised from partially saturated phenanthridinones, 6 and 7, respectively via epoxidation and trans opening of the epoxides. Compounds 16 and 17, cis analogues of 13 were also synthesised from 7 via cis dihydroxylation with catalytic osmium tetroxide and N‐methylmorpholine N‐oxide. The stereoisomers obtained were separated by column chromatography after protection of the hydroxyl groups. The products synthesised are characterised satisfactorily by ir, nmr, ms and microanalysis data and are expected to possess anticancer or antiviral activity.

📜 SIMILAR VOLUMES

ChemInform Abstract: Synthesis of Severa
ChemInform Abstract: Synthesis of Several Deoxy Analogues of Pancratistatin.
✍ L. BALAZS; I. KADAS; L. TOKE 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 1 views

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